INTERNATIONAL RESEARCH JOURNAL OF SCIENCE ENGINEERING AND TECHNOLOGY
( Online- ISSN 2454 -3195 ) New DOI : 10.32804/RJSET
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KINETICS AND MECHANISTIC STUDY OF OXIDATION OF PIRBUTEROL BY KEGGINTYPE 12 TUNGSTOCOBALTATE (III) IN AQUEOUS ACIDIC MEDIUM
5 Author(s): R. N. SALUNKE ,S. N. ZENDE,D. A. KUMBHAR ,B. D. AJALKAR, J.P. SINGH
Vol - 7, Issue- 1 , Page(s) : 108 - 116 (2017 ) DOI : https://doi.org/10.32804/RJSET
By the spectrophotometric method, the kinetics and mechanism of oxidation of asthmatic drug Pirbuterol and Keggin type 12-tungstocobaltate (III)in aqueous acidic medium was studied at 624nm wavelength and temperature 25±0.20C under pseudo-first order conditions. At a constant ionic strength of 0.3 mol dm-3 the reaction exhibits 1:2 stoichiometry. The identification of product was done by 1H NMR, LC-Mass, spot test, IR, and M. P. The reaction constant in the different steps of the mechanism has been calculated and the ionic strength of the reaction medium and effect of H+ ion are investigated. The activation parameters with respect to slow step of the mechanism are computed and discussed. A mechanism related to this reaction is proposed.