Preventing MRR / XDR-TD is a high priority of global tuber control because of the need to curb disease expansion and the high cost toxicity, poor treatment outcomes of available therapies .. Prevent MRR-XDR-TB is a top priority for global TB management. TB prevention We conducted a systemic literature review to assess evidence of strategies for reducing transmission and progression of MDR / XDR-TB. Rapid detection and effective treatment initiation are essential to make non-infectious cases of MDR / XDR-TB. Rapid molecular tests increased the ability to identify and treat patients with MDR / XDR-TB in high-incidence settings. In order to protect both patients and medical staff, automated infection control measures in hospitals and clinics are necessary. Innovative measures to reduce transmission in community locations are required. Targeted screening of high-risk communities can improve early case detection and reduce MDR / XDRTB spread. Preventive therapy promises among infected contacts to reduce the risk of progression of the disease. This is confirmed by observational observations but, to validate these findings and inform policy formulation, randomized trials are urgently needed. If the ambitious global goal of TB removal is to be achieved, significant investments are to be made in preventing and treating MDR / XDR-TB.