INTERNATIONAL RESEARCH JOURNAL OF SCIENCE ENGINEERING AND TECHNOLOGY

( Online- ISSN 2454 -3195 ) New DOI : 10.32804/RJSET

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SYNTHESIS OF SOME NEW COUMARIN DERIVATIVES AND STUDY OF THEIR BIOLOGICAL ACTIVITY

    1 Author(s):  DR. RINKY KUMARI

Vol -  10, Issue- 2 ,         Page(s) : 185 - 191  (2020 ) DOI : https://doi.org/10.32804/RJSET

Abstract

Alkylation of (3b) with either 2-furoyl chloride or chloroacetyl chloride gave the 2-N-substituted derivatives (5a,b). Benzofurano[3,2-b]4H-pyranderivative (8) was also prepared. Compund (6) was prepared by refluxing a mixture of (5b) and sodium metal in absolute ethanol. Treatment of (3b) with 4-bromophenacylbromide gave compound (7). The antimicrobial activity of the prepared compounds wastested.

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